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Sleep Science Podcast
We spend a third of our lives sleeping, and this podcast is all about understanding sleep. We know a lot about what the brain does in sleep, but we are just starting to understand why it does some of these things, and even more excitingly, how we can take full advantage of sleep and also manipulate it for our own ends. In each episode, neuroscientist Penny Lewis interviews a different sleep researcher, talking about a various aspect of sleep science. Topics include sleep physiology and medicine, circadian rhythm, how sleep impacts on our memories and creativity, Sleep Engineering for enhanced health and cognition, and the most recent technologies to promote sleep.©SleepSciencePodcast 2021. These materials may be downloaded for personal use only. They may not be shared, distributed or reproduced in any form or for any reason without express permission
Sleep Science Podcast
S3E6 - Hongi Ngo: Exploring Closed-Loop Auditory Stimulation
We're joined by Hongi Ngo, who developed a revolutionary technique for manipulating sleep oscillations during his PhD. Closed-loop Auditory Stimulation (CLAS), which uses bursts of pink noise which are carefully timed to a particular phase of an existing brain oscillation to either boost or dampen the target oscillation. It has been used to selectively strengthen or weaken memories, improve the immune response, reduce epileptic seizures, and even potentially to slow down age related cognitive decline.
Hongi tells us how he got got the idea for CLAS, explains how it works, and tells us about some of his existing studies. He talks about combining CLAS with Targeted Memory Reactivation (TMR) and discusses the ideas for future of brain modulation methods with techniques such as transcranial magnetic stimulation (TMS).
Some of the key papers discussed are:
Auditory closed-loop stimulation of the sleep slow oscillation enhances memory (2013)
Shaping overnight consolidation via slow-oscillation closed-loop targeted memory reactivation (2022)
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